[HTML][HTML] Reactive oxygen species, AMP-activated protein kinase, and the transcription cofactor p300 regulate α-tubulin acetyltransferase-1 (αTAT-1/MEC-17) …
R Mackeh, S Lorin, A Ratier, N Mejdoubi-Charef… - Journal of Biological …, 2014 - ASBMB
Beyond its presence in stable microtubules, tubulin acetylation can be boosted after UV
exposure or after nutrient deprivation, but the mechanisms of microtubule hyperacetylation
are still unknown. In this study, we show that this hyperacetylation is a common response to
several cellular stresses that involves the stimulation of the major tubulin acetyltransferase
MEC-17. We also demonstrate that the acetyltransferase p300 negatively regulates MEC-17
expression and is sequestered on microtubules upon stress. We further show that reactive …
exposure or after nutrient deprivation, but the mechanisms of microtubule hyperacetylation
are still unknown. In this study, we show that this hyperacetylation is a common response to
several cellular stresses that involves the stimulation of the major tubulin acetyltransferase
MEC-17. We also demonstrate that the acetyltransferase p300 negatively regulates MEC-17
expression and is sequestered on microtubules upon stress. We further show that reactive …