To date, the only intervention that has consistently been shown to slow the rate of aging, and
to increase mean and maximum lifespan in short-lived species, is life-long calorie restriction.
It is yet unclear whether long-term calorie restriction in longer lived species (ie primates and
humans) will have a similar effect. In humans, several studies investigating short-term
calorie restriction or “weight loss” programs suggest beneficial outcomes on parameters of
cardiovascular disease. Studies on long-term calorie restriction are performed on a self …