[HTML][HTML] MicroRNA expression characterizes oligometastasis (es)
YA Lussier, HR Xing, JK Salama, NN Khodarev… - PloS one, 2011 - journals.plos.org
PloS one, 2011•journals.plos.org
Background Cancer staging and treatment presumes a division into localized or metastatic
disease. We proposed an intermediate state defined by≤ 5 cumulative metastasis (es),
termed oligometastases. In contrast to widespread polymetastases, oligometastatic patients
may benefit from metastasis-directed local treatments. However, many patients who initially
present with oligometastases progress to polymetastases. Predictors of progression could
improve patient selection for metastasis-directed therapy. Methods Here, we identified …
disease. We proposed an intermediate state defined by≤ 5 cumulative metastasis (es),
termed oligometastases. In contrast to widespread polymetastases, oligometastatic patients
may benefit from metastasis-directed local treatments. However, many patients who initially
present with oligometastases progress to polymetastases. Predictors of progression could
improve patient selection for metastasis-directed therapy. Methods Here, we identified …
Background
Cancer staging and treatment presumes a division into localized or metastatic disease. We proposed an intermediate state defined by ≤5 cumulative metastasis(es), termed oligometastases. In contrast to widespread polymetastases, oligometastatic patients may benefit from metastasis-directed local treatments. However, many patients who initially present with oligometastases progress to polymetastases. Predictors of progression could improve patient selection for metastasis-directed therapy.
Methods
Here, we identified patterns of microRNA expression of tumor samples from oligometastatic patients treated with high-dose radiotherapy.
Results
Patients who failed to develop polymetastases are characterized by unique prioritized features of a microRNA classifier that includes the microRNA-200 family. We created an oligometastatic-polymetastatic xenograft model in which the patient-derived microRNAs discriminated between the two metastatic outcomes. MicroRNA-200c enhancement in an oligometastatic cell line resulted in polymetastatic progression.
Conclusions
These results demonstrate a biological basis for oligometastases and a potential for using microRNA expression to identify patients most likely to remain oligometastatic after metastasis-directed treatment.
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