Immunosuppressive mechanisms in the microenvironment of malignant pleural effusions
JJ Sikora, GT Dworacki, MT Kaczmarek… - Cancer Detection and …, 2004 - Elsevier
Malignant effusions in serous cavities constitute a unique milieu for direct contact of tumor
cells with host lymphoid cells in a fluid phase. The aim of this study was to depict agents
responsible for suppression of lymphoid cells with putative anti-tumor potential. Pleural
effusions drawn from 44 (18 non-malignant and 26 malignant) patients were tested for
selected cytokines—interleukin-10 (IL-10), transforming growth factor beta (TGF-β1) and
soluble Fas ligand (sFasL) and nuclear membrane proteins (NMPs) content by ELISA. TCR …
cells with host lymphoid cells in a fluid phase. The aim of this study was to depict agents
responsible for suppression of lymphoid cells with putative anti-tumor potential. Pleural
effusions drawn from 44 (18 non-malignant and 26 malignant) patients were tested for
selected cytokines—interleukin-10 (IL-10), transforming growth factor beta (TGF-β1) and
soluble Fas ligand (sFasL) and nuclear membrane proteins (NMPs) content by ELISA. TCR …