Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells
R Derynck, JA Jarrett, EY Chen, DH Eaton, JR Bell… - Nature, 1985 - nature.com
R Derynck, JA Jarrett, EY Chen, DH Eaton, JR Bell, RK Assoian, AB Roberts, MB Sporn…
Nature, 1985•nature.comThe partial amino-acid sequence of purified human transforming growth factor-β (TGF-β)
was used to identify a series of cDNA clones encoding the protein. The cDNA sequence
indicates that the 112-amino acid monomeric form of the natural TGF-β homodimer is
derived proteolytically from a much longer precursor polypeptide which may be secreted.
TGF-β messenger RNA is synthesized in various normal and transformed cells.
was used to identify a series of cDNA clones encoding the protein. The cDNA sequence
indicates that the 112-amino acid monomeric form of the natural TGF-β homodimer is
derived proteolytically from a much longer precursor polypeptide which may be secreted.
TGF-β messenger RNA is synthesized in various normal and transformed cells.
Abstract
The partial amino-acid sequence of purified human transforming growth factor-β (TGF-β) was used to identify a series of cDNA clones encoding the protein. The cDNA sequence indicates that the 112-amino acid monomeric form of the natural TGF-β homodimer is derived proteolytically from a much longer precursor polypeptide which may be secreted. TGF-β messenger RNA is synthesized in various normal and transformed cells.
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