[HTML][HTML] The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides
G Jedlitschky, B Burchell, D Keppler - Journal of Biological Chemistry, 2000 - ASBMB
Cellular export of cyclic nucleotides has been observed in various tissues and may
represent an elimination pathway for these signaling molecules, in addition to degradation
by phosphodiesterases. In the present study we provide evidence that this export is
mediated by the multidrug resistance protein isoform MRP5 (gene symbol ABCC5). The
transport function of MRP5 was studied in V79 hamster lung fibroblasts transfected with a
human MRP5 cDNA. An MRP5-specific antibody detected an overexpression of the …
represent an elimination pathway for these signaling molecules, in addition to degradation
by phosphodiesterases. In the present study we provide evidence that this export is
mediated by the multidrug resistance protein isoform MRP5 (gene symbol ABCC5). The
transport function of MRP5 was studied in V79 hamster lung fibroblasts transfected with a
human MRP5 cDNA. An MRP5-specific antibody detected an overexpression of the …