Cyclic GMP transporters
G Sager - Neurochemistry international, 2004 - Elsevier
The biokinetics of guanosine 3′, 5′-cyclic monophosphate (cGMP) is characterized by
three distinct processes: synthesis by guanylate cyclases (GCs), conversion of cGMP to
GMP by cyclic nucleotide phosphodiesterases (PDEs) and the excretion of unchanged
cGMP by transport proteins in the cell membrane. Efflux is observed in virtually all cell types
including cells which originate from brain. Studies of intact cells, in which metabolic
inhibitors and probenecid reduced extrusion of cGMP and wherein cGMP was extruded …
three distinct processes: synthesis by guanylate cyclases (GCs), conversion of cGMP to
GMP by cyclic nucleotide phosphodiesterases (PDEs) and the excretion of unchanged
cGMP by transport proteins in the cell membrane. Efflux is observed in virtually all cell types
including cells which originate from brain. Studies of intact cells, in which metabolic
inhibitors and probenecid reduced extrusion of cGMP and wherein cGMP was extruded …