The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

JM Adams, AW Harris, CA Pinkert, LM Corcoran… - Nature, 1985 - nature.com
JM Adams, AW Harris, CA Pinkert, LM Corcoran, WS Alexander, S Cory, RD Palmiter…
Nature, 1985nature.com
Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin μ or κ
enhancer frequently develop a fatal lymphoma within a few months of birth. Since the
tumours represent both immature and mature B lymphocytes, constitutive c-myc expression
appears to be highly leukaemogenic at several stages of B-cell maturation. These myc mice
should aid study of lymphoma development, B-cell ontogeny and immunoglobulin
regulation.
Abstract
Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin μ or κ enhancer frequently develop a fatal lymphoma within a few months of birth. Since the tumours represent both immature and mature B lymphocytes, constitutive c-myc expression appears to be highly leukaemogenic at several stages of B-cell maturation. These myc mice should aid study of lymphoma development, B-cell ontogeny and immunoglobulin regulation.
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