Common variants at 5q22 associate with pediatric eosinophilic esophagitis
Nature genetics, 2010•nature.com
Eosinophilic esophagitis (EoE) is an allergic disorder characterized by the accumulation of
eosinophils in the esophagus. We report association of EoE with variants at chromosome
5q22 encompassing TSLP and WDR36 (rs3806932, combined P= 3.19× 10− 9). TSLP is
overexpressed in esophageal biopsies from individuals with EoE compared with unaffected
individuals, whereas WDR36 expression is unaltered between the two groups. These data
implicate the 5q22 locus in the pathogenesis of EoE and identify TSLP as the most likely …
eosinophils in the esophagus. We report association of EoE with variants at chromosome
5q22 encompassing TSLP and WDR36 (rs3806932, combined P= 3.19× 10− 9). TSLP is
overexpressed in esophageal biopsies from individuals with EoE compared with unaffected
individuals, whereas WDR36 expression is unaltered between the two groups. These data
implicate the 5q22 locus in the pathogenesis of EoE and identify TSLP as the most likely …
Abstract
Eosinophilic esophagitis (EoE) is an allergic disorder characterized by the accumulation of eosinophils in the esophagus. We report association of EoE with variants at chromosome 5q22 encompassing TSLP and WDR36 (rs3806932, combined P = 3.19 × 10−9). TSLP is overexpressed in esophageal biopsies from individuals with EoE compared with unaffected individuals, whereas WDR36 expression is unaltered between the two groups. These data implicate the 5q22 locus in the pathogenesis of EoE and identify TSLP as the most likely candidate gene in the region.
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