Hereditary spastic paraplegias with autosomal dominant, recessive, X-linked, or maternal trait of inheritance
J Finsterer, W Löscher, S Quasthoff, J Wanschitz… - Journal of the …, 2012 - Elsevier
Hereditary spastic paraplegia (SPG) is a clinically and genetically heterogeneous group of
neurodegenerative disorders that are clinically characterised by progressive spasticity and
weakness of the lower-limbs (pure SPG) and, majoritorian, additional more extensive
neurological or non-neurological manifestations (complex or complicated SPG). Pure SPG is
characterised by progressive spasticity and weakness of the lower-limbs, and occasionally
sensory disturbances or bladder dysfunction. Complex SPGs additionally include cognitive …
neurodegenerative disorders that are clinically characterised by progressive spasticity and
weakness of the lower-limbs (pure SPG) and, majoritorian, additional more extensive
neurological or non-neurological manifestations (complex or complicated SPG). Pure SPG is
characterised by progressive spasticity and weakness of the lower-limbs, and occasionally
sensory disturbances or bladder dysfunction. Complex SPGs additionally include cognitive …