Immunopathogenesis and role of T cells in psoriasis
K Ghoreschi, C Weigert, M Röcken - Clinics in dermatology, 2007 - Elsevier
Psoriasis is a T cell–dependent autoimmune disease of the skin and joints. Disease
manifestation is orchestrated by proinflammatory CD4-positive T helper cells producing
either interferon-γ (Th1) or interleukin (IL)-17 (Th17). These Th1 and Th17 cells interact with
dermal dendritic cells, macrophages, mast cells, and neutrophils. Together, they cause an
inflammation that mainly involves interferon-γ, tumor necrosis factor, IL-8, IL-12, IL-17, IL-19,
and IL-23. New therapeutics either are directed against T cells, tumor necrosis factor, and IL …
manifestation is orchestrated by proinflammatory CD4-positive T helper cells producing
either interferon-γ (Th1) or interleukin (IL)-17 (Th17). These Th1 and Th17 cells interact with
dermal dendritic cells, macrophages, mast cells, and neutrophils. Together, they cause an
inflammation that mainly involves interferon-γ, tumor necrosis factor, IL-8, IL-12, IL-17, IL-19,
and IL-23. New therapeutics either are directed against T cells, tumor necrosis factor, and IL …