Mitochondrial protein thiol modifications in acetaminophen hepatotoxicity: effect on HMG-CoA synthase
KK Andringa, ML Bajt, H Jaeschke, SM Bailey - Toxicology letters, 2008 - Elsevier
Acetaminophen (APAP) overdose is the leading cause of drug related liver failure in many
countries. N-acetyl-p-benzoquinone imine (NAPQI) is a reactive metabolite that is formed by
the metabolism of APAP. NAPQI preferentially binds to glutathione and then cellular
proteins. NAPQI binding is considered an upstream event in the pathophysiology, especially
when binding to mitochondrial proteins and therefore leads to mitochondrial toxicity. APAP
caused a significant increase in liver toxicity 3h post-APAP administration as measured by …
countries. N-acetyl-p-benzoquinone imine (NAPQI) is a reactive metabolite that is formed by
the metabolism of APAP. NAPQI preferentially binds to glutathione and then cellular
proteins. NAPQI binding is considered an upstream event in the pathophysiology, especially
when binding to mitochondrial proteins and therefore leads to mitochondrial toxicity. APAP
caused a significant increase in liver toxicity 3h post-APAP administration as measured by …