Decreased expressions of vascular endothelial growth factor and visfatin in the placental bed of pregnancies complicated by preeclampsia
SC Kim, MJ Park, BS Joo, JK Joo… - Journal of Obstetrics …, 2012 - Wiley Online Library
SC Kim, MJ Park, BS Joo, JK Joo, DS Suh, KS Lee
Journal of Obstetrics and Gynaecology Research, 2012•Wiley Online LibraryAim: The aim of the present study was to examine the expression of vascular endothelial
growth factor (VEGF) and visfatin in the third trimester placental bed of pregnancies with and
without preeclampsia (PE). Material and Methods: The study group consisted of placental
bed biopsy tissues obtained from pregnancies with (n= 20) and without (n= 20) PE. The
normotensive controls without PE were matched for gestational age at delivery with patients
with PE. The expression of VEGF and visfatin in the placental bed tissues were evaluated …
growth factor (VEGF) and visfatin in the third trimester placental bed of pregnancies with and
without preeclampsia (PE). Material and Methods: The study group consisted of placental
bed biopsy tissues obtained from pregnancies with (n= 20) and without (n= 20) PE. The
normotensive controls without PE were matched for gestational age at delivery with patients
with PE. The expression of VEGF and visfatin in the placental bed tissues were evaluated …
Abstract
Aim: The aim of the present study was to examine the expression of vascular endothelial growth factor (VEGF) and visfatin in the third trimester placental bed of pregnancies with and without preeclampsia (PE).
Material and Methods: The study group consisted of placental bed biopsy tissues obtained from pregnancies with (n = 20) and without (n = 20) PE. The normotensive controls without PE were matched for gestational age at delivery with patients with PE. The expression of VEGF and visfatin in the placental bed tissues were evaluated using reverse transcriptase‐polymerase chain reaction (RT‐PCR), real‐time polymerase chain reaction (PCR), immunohistochemistry and Western blot.
Results: There was no statistical difference between the PE group and the normotensive control group in age and body mass index (BMI). The expression of VEGF and visfatin was significantly decreased in the PE group compared with the normotensive control group (P < 0.05).
Conclusion: This study showed decreased expressions of VEGF and visfatin in the third trimester placental bed of pregnancies with PE compared with the normotensive controls. This result suggests that decreased expression of these angiogenic factors in placental bed may be associated with the pathogenesis of PE.
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