High fat diet induced diabetic cardiomyopathy
E Dirkx, RW Schwenk, JFC Glatz, JJFP Luiken… - … and Essential Fatty …, 2011 - Elsevier
In response to a chronic high plasma concentration of long-chain fatty acids (FAs), the heart
is forced to increase the uptake of FA at the cost of glucose. This switch in metabolic
substrate uptake is accompanied by an increased presence of the FA transporter CD36 at
the cardiac plasma membrane and over time results in the development of cardiac insulin
resistance and ultimately diabetic cardiomyopathy. FA can interact with peroxisome
proliferator-activated receptors (PPARs), which induce upregulation of the expression of …
is forced to increase the uptake of FA at the cost of glucose. This switch in metabolic
substrate uptake is accompanied by an increased presence of the FA transporter CD36 at
the cardiac plasma membrane and over time results in the development of cardiac insulin
resistance and ultimately diabetic cardiomyopathy. FA can interact with peroxisome
proliferator-activated receptors (PPARs), which induce upregulation of the expression of …