[HTML][HTML] Peroxisome proliferator-activated receptor α negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF …
P Delerive, K De Bosscher, S Besnard… - Journal of Biological …, 1999 - ASBMB
Interleukin-6 (IL-6) is a pleiotropic cytokine, whose plasma levels are elevated in
inflammatory diseases such as atherosclerosis. We have previously reported that
peroxisome proliferator-activated receptor α (PPARα) ligands (fibrates) lower elevated
plasma concentrations of IL-6 in patients with atherosclerosis and inhibit IL-1-stimulated IL-6
secretion by human aortic smooth muscle cells (SMC). Here, we show that aortic explants
isolated from PPARα-null mice display an exacerbated response to inflammatory stimuli …
inflammatory diseases such as atherosclerosis. We have previously reported that
peroxisome proliferator-activated receptor α (PPARα) ligands (fibrates) lower elevated
plasma concentrations of IL-6 in patients with atherosclerosis and inhibit IL-1-stimulated IL-6
secretion by human aortic smooth muscle cells (SMC). Here, we show that aortic explants
isolated from PPARα-null mice display an exacerbated response to inflammatory stimuli …