Graft-versus-host disease (GvHD) is the major cause of transplant-related mortality and
morbidity. As it is closely related to the major therapeutic principle, graft-versus-leukaemia
(GvL) effect, risk assessment has to balance both risks depending on the pre-transplant
status. This is clearly demonstrated when comparing the two major strategies for prevention
of GvHD. While the majority of approaches aiming at T-cell depletion show efficacy in
reducing acute and chronic GvHD and transplant-related mortality, T-cell depletion also …