[HTML][HTML] Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control

RC Noland, TR Koves, SE Seiler, H Lum… - Journal of biological …, 2009 - ASBMB
In addition to its essential role in permitting mitochondrial import and oxidation of long chain
fatty acids, carnitine also functions as an acyl group acceptor that facilitates mitochondrial
export of excess carbons in the form of acylcarnitines. Recent evidence suggests carnitine
requirements increase under conditions of sustained metabolic stress. Accordingly, we
hypothesized that carnitine insufficiency might contribute to mitochondrial dysfunction and
obesity-related impairments in glucose tolerance. Consistent with this prediction whole body …