SPAK differentially mediates vasopressin effects on sodium cotransporters
T Saritas, A Borschewski, JA McCormick… - Journal of the …, 2013 - journals.lww.com
Activation of the Na+-K+-2Cl−-cotransporter (NKCC2) and the Na+-Cl−-cotransporter (NCC)
by vasopressin includes their phosphorylation at defined, conserved N-terminal threonine
and serine residues, but the kinase pathways that mediate this action of vasopressin are not
well understood. Two homologous Ste20-like kinases, SPS-related proline/alanine-rich
kinase (SPAK) and oxidative stress responsive kinase (OSR1), can phosphorylate the
cotransporters directly. In this process, a full-length SPAK variant and OSR1 interact with a …
by vasopressin includes their phosphorylation at defined, conserved N-terminal threonine
and serine residues, but the kinase pathways that mediate this action of vasopressin are not
well understood. Two homologous Ste20-like kinases, SPS-related proline/alanine-rich
kinase (SPAK) and oxidative stress responsive kinase (OSR1), can phosphorylate the
cotransporters directly. In this process, a full-length SPAK variant and OSR1 interact with a …