[HTML][HTML] Effect of the structure of the N terminus of tropomyosin on tropomodulin function

AS Kostyukova, SE Hitchcock-DeGregori - Journal of Biological Chemistry, 2004 - ASBMB
Tropomodulins (Tmod) bind to the N terminus of tropomyosin and cap the pointed end of
actin filaments. Tropomyosin alone also inhibits the rate of actin depolymerization at the
pointed end of filaments. Here we have defined 1) the structural requirements of the N
terminus of tropomyosin important for regulating the pointed end alone and with erythrocyte
Tmod (Tmod1), and 2) the Tmod1 subdomains required for binding to tropomyosin and for
regulating the pointed end. Changes in pyrene-actin fluorescence during polymerization …