Inhibition of the ABL kinase activity blocks the proliferation of BCR/ABL+ leukemic cells and induces apoptosis
The BCR/ABL fusion protein transforms myeloid stem cells. Both chronic myelogenous
leukemias (CML) and a subset of acute lymphoblastic leukemias (ALL) are associated with
the expression of BCR/ABL proteins. This knowledge has not yet been translated into any
specific tool to control ABL driven neoplastic cells growth. CGP57148B is an ATP-
competitive inhibitor of the ABL protein kinase; it has been shown to inhibit the kinase
activity of ABL bothin vitroandin vivoand to inhibit the growth of v-abl and bcr/abl …
leukemias (CML) and a subset of acute lymphoblastic leukemias (ALL) are associated with
the expression of BCR/ABL proteins. This knowledge has not yet been translated into any
specific tool to control ABL driven neoplastic cells growth. CGP57148B is an ATP-
competitive inhibitor of the ABL protein kinase; it has been shown to inhibit the kinase
activity of ABL bothin vitroandin vivoand to inhibit the growth of v-abl and bcr/abl …