Sublingual immunotherapy induces IL-10–producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation
B Bohle, T Kinaciyan, M Gerstmayr… - Journal of Allergy and …, 2007 - Elsevier
BACKGROUND: The immunologic mechanisms underlying sublingual immunotherapy
(SLIT) are still unclear, particularly the role of regulatory T cells. OBJECTIVE: We sought to
characterize allergen-specific T-cell responses during successful birch pollen SLIT.
METHODS: Proliferation of PBMCs and PBMCs depleted of CD25+ cells obtained from 9
patients before, after 4 weeks, and after 52 weeks of SLIT was assessed in response to the
major birch pollen allergen Bet v 1, the homologous apple allergen Mal d 1, or tetanus …
(SLIT) are still unclear, particularly the role of regulatory T cells. OBJECTIVE: We sought to
characterize allergen-specific T-cell responses during successful birch pollen SLIT.
METHODS: Proliferation of PBMCs and PBMCs depleted of CD25+ cells obtained from 9
patients before, after 4 weeks, and after 52 weeks of SLIT was assessed in response to the
major birch pollen allergen Bet v 1, the homologous apple allergen Mal d 1, or tetanus …