Dipeptidyl-peptidase I, a lysosomal cysteine proteinase, is important in intracellular
degradation of proteins and appears to be a central coordinator for activation of many serine
proteinases in immune/inflammatory cells. Little is known about the molecular genetics of
the enzyme. In the present investigation the gene for dipeptidyl-peptidase I was cloned and
characterized. The gene spans approximately 3.5 kilobases and consists of two exons and
one intron. The genomic organization is distinct from the complex structures of the other …