“The Race” to Clone BRCA1
MC King - Science, 2014 - science.org
Science, 2014•science.org
The existence of BRCA1 was proven in 1990 by mapping predisposition to young-onset
breast cancer in families to chromosome 17q21. Knowing that such a gene existed and
approximately where it lay triggered efforts by public and private groups to clone and
sequence it. The press baptized the competition “the race” and reported on it in detail for the
next 4 years. BRCA1 was positionally cloned in September 1994. Twenty years later, I reflect
on “the race” and its consequences for breast cancer prevention and treatment.
breast cancer in families to chromosome 17q21. Knowing that such a gene existed and
approximately where it lay triggered efforts by public and private groups to clone and
sequence it. The press baptized the competition “the race” and reported on it in detail for the
next 4 years. BRCA1 was positionally cloned in September 1994. Twenty years later, I reflect
on “the race” and its consequences for breast cancer prevention and treatment.
The existence of BRCA1 was proven in 1990 by mapping predisposition to young-onset breast cancer in families to chromosome 17q21. Knowing that such a gene existed and approximately where it lay triggered efforts by public and private groups to clone and sequence it. The press baptized the competition “the race” and reported on it in detail for the next 4 years. BRCA1 was positionally cloned in September 1994. Twenty years later, I reflect on “the race” and its consequences for breast cancer prevention and treatment.
AAAS