[HTML][HTML] Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen …

H Peng, M Guerau-de-Arellano, VB Mehta… - Journal of Biological …, 2012 - ASBMB
Dimethyl fumarate (DMF) is an effective novel treatment for multiple sclerosis in clinical trials.
A reduction of IFN-γ-producing CD4+ T cells is observed in DMF-treated patients and may
contribute to its clinical efficacy. However, the cellular and molecular mechanisms behind
this clinical observation are unclear. In this study, we investigated the effects of DMF on
dendritic cell (DC) maturation and subsequent DC-mediated T cell responses. We show that
DMF inhibits DC maturation by reducing inflammatory cytokine production (IL-12 and IL-6) …