[HTML][HTML] Heme-based globin-coupled oxygen sensors: linking oxygen binding to functional regulation of diguanylate cyclase, histidine kinase, and methyl-accepting …

M Martínková, K Kitanishi, T Shimizu - Journal of Biological Chemistry, 2013 - ASBMB
An emerging class of novel heme-based oxygen sensors containing a globin fold binds and
senses environmental O 2 via a heme iron complex. Structure-function relationships of
oxygen sensors containing a heme-bound globin fold are different from those containing
heme-bound PAS and GAF folds. It is thus worth reconsidering from an evolutionary
perspective how heme-bound proteins with a globin fold similar to that of hemoglobin and
myoglobin could act as O 2 sensors. Here, we summarize the molecular mechanisms of …