[HTML][HTML] Negative regulation of NF-κB and its involvement in rheumatoid arthritis

G van Loo, R Beyaert - Arthritis research & therapy, 2011 - Springer
G van Loo, R Beyaert
Arthritis research & therapy, 2011Springer
The transcription factor NF-κB plays crucial roles in the regulation of inflammation and
mmune responses, and inappropriate NF-κB activity has been linked with many autoimmune
and inflammatory diseases, including rheumatoid arthritis. Cells employ a multilayered
control system to keep NF-κB signalling in check, including a repertoire of negative feedback
regulators ensuring termination of NF-κB responses. Here we will review various negative
regulatory mechanisms that have evolved to control NF-κB signalling and which have been …
Abstract
The transcription factor NF-κB plays crucial roles in the regulation of inflammation and mmune responses, and inappropriate NF-κB activity has been linked with many autoimmune and inflammatory diseases, including rheumatoid arthritis. Cells employ a multilayered control system to keep NF-κB signalling in check, including a repertoire of negative feedback regulators ensuring termination of NF-κB responses. Here we will review various negative regulatory mechanisms that have evolved to control NF-κB signalling and which have been implicated in the pathogenesis of rheumatoid arthritis.
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