Inner ear autoantibodies in patients with rapidly progressive sensorineural hearing loss
JP Harris, PA Sharp - The Laryngoscope, 1990 - Wiley Online Library
JP Harris, PA Sharp
The Laryngoscope, 1990•Wiley Online LibraryRecognition of immune‐mediated sensorineural deafness that responds to
immunosuppressive therapy has led to a search for a diagnostic assay to identify inner ear
autoantibodies. Without a confirmed diagnosis of autoimmune disease, many patients have
undergone inappropriate immunosuppressive treatment or developed irreversible inner ear
damage. Serum from patients with progressive sensorineural hearing loss (N= 54),
ulcerative colitis (N= 5), normal controls (N= 14), and animals with experimental …
immunosuppressive therapy has led to a search for a diagnostic assay to identify inner ear
autoantibodies. Without a confirmed diagnosis of autoimmune disease, many patients have
undergone inappropriate immunosuppressive treatment or developed irreversible inner ear
damage. Serum from patients with progressive sensorineural hearing loss (N= 54),
ulcerative colitis (N= 5), normal controls (N= 14), and animals with experimental …
Abstract
Recognition of immune‐mediated sensorineural deafness that responds to immunosuppressive therapy has led to a search for a diagnostic assay to identify inner ear autoantibodies. Without a confirmed diagnosis of autoimmune disease, many patients have undergone inappropriate immunosuppressive treatment or developed irreversible inner ear damage.
Serum from patients with progressive sensorineural hearing loss (N=54), ulcerative colitis (N=5), normal controls (N=14), and animals with experimental autoimmune sensorineural hearing loss (EASNHL) were analyzed by Western blot against fresh bovine inner ear antigen preparations. The hearing loss group (19 [35%]) showed a single‐or double‐band migrating at 68,000 molecular weight (MW), differing from the normal group (1 of 14 [7%]) which showed a similar band (P = .031).
Upon analysis by two‐dimensional gel electrophoresis both the EASNHL guinea pigs and a patient reacted against identical components of inner ear antigen. These results suggest an autoimmune basis for disease in patients reacting against the 68,000 MW antigen.
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