Continuous growth of mean tumor diameter in a subset of grade II gliomas

E Mandonnet, JY Delattre, ML Tanguy… - Annals of Neurology …, 2003 - Wiley Online Library
E Mandonnet, JY Delattre, ML Tanguy, KR Swanson, AF Carpentier, H Duffau, P Cornu…
Annals of Neurology: Official Journal of the American Neurological …, 2003Wiley Online Library
Serial magnetic resonance images of 27 patients with untreated World Health Organization
grade II oligodendrogliomas or mixed gliomas were reviewed retrospectively to study the
kinetics of tumor growth before anaplastic transformation. Analysis of the mean tumor
diameters over time showed constant growth. Linear regression, using a mixed model, found
an average slope of 4.1 mm per year (95% confidence interval, 3.8–4.4 mm/year). Untreated
low‐grade oligodendrogliomas or mixed gliomas grow continuously during their …
Abstract
Serial magnetic resonance images of 27 patients with untreated World Health Organization grade II oligodendrogliomas or mixed gliomas were reviewed retrospectively to study the kinetics of tumor growth before anaplastic transformation. Analysis of the mean tumor diameters over time showed constant growth. Linear regression, using a mixed model, found an average slope of 4.1mm per year (95% confidence interval, 3.8–4.4mm/year). Untreated low‐grade oligodendrogliomas or mixed gliomas grow continuously during their premalignant phase, and their pattern of growth can be predicted within a relatively narrow range. These findings could be of interest to optimize patients management and follow‐up. Ann Neurol 2003;53:524–528
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