[HTML][HTML] Pivotal involvement of Fcγ receptor IIA in the neutralization of lipopolysaccharide signaling via a potent novel anti-TLR4 monoclonal antibody 15C1
I Dunn-Siegrist, O Leger, B Daubeuf, Y Poitevin… - Journal of biological …, 2007 - ASBMB
The mammalian Toll-like receptor (TLR) family has evolved to sense pathogens in the
environment and protect the host against infection. TLR4 recognizes lipopolysaccharide
(LPS) from Gram-negative bacteria and induces a signaling cascade that, when
exaggerated, has been associated with severe sepsis. We have generated a TLR4-specific
monoclonal antibody, 15C1, which neutralizes LPS-induced TLR4 activation in a dose-
dependent manner. 15C1 potently blocks the effects of LPS on a panel of primary cells and …
environment and protect the host against infection. TLR4 recognizes lipopolysaccharide
(LPS) from Gram-negative bacteria and induces a signaling cascade that, when
exaggerated, has been associated with severe sepsis. We have generated a TLR4-specific
monoclonal antibody, 15C1, which neutralizes LPS-induced TLR4 activation in a dose-
dependent manner. 15C1 potently blocks the effects of LPS on a panel of primary cells and …