A new concept for acne therapy: a pilot study with zileuton, an oral 5-lipoxygenase inhibitor

CC Zouboulis, S Nestoris, YD Adler, M Orth… - Archives of …, 2003 - jamanetwork.com
The leukotrienes, a family of highly potent biological substances derived from arachidonic
acid, are suggested to play an important role in the development of tissue inflammation. 1
Leukotriene B 4 (LTB 4) is a major player whose synthesis is mainly controlled by 5-
lipoxygenase. Among several diseases, hyperkeratotic inflammatory skin diseases and
especially psoriasis seem to respond to LTB 4 inhibitors. 2 Recent study findings indicate
the potential involvement of the arachidonic acid pathway in the development of …