Relationships between the functional PPARα Leu162Val polymorphism and obesity, type 2 diabetes, dyslipidaemia, and related quantitative traits in studies of 5799 …
T Sparsø, MS Hussain, G Andersen, I Hainerova… - Molecular genetics and …, 2007 - Elsevier
Peroxisome proliferator-activated receptor-α (PPARα) is a nuclear receptor capable of
regulating the expression of genes involved in peroxisomal and mitochondrial β-oxidation
pathways. The common Leu162Val polymorphism in the gene encoding PPARα has
inconsistently shown association with quantitative traits related to obesity, type 2 diabetes,
and dyslipidaemia. We genotyped the Leu162Val polymorphism in 1383 patients with type 2
diabetes and 4401 control subjects with normal glucose tolerance (NGT) without showing …
regulating the expression of genes involved in peroxisomal and mitochondrial β-oxidation
pathways. The common Leu162Val polymorphism in the gene encoding PPARα has
inconsistently shown association with quantitative traits related to obesity, type 2 diabetes,
and dyslipidaemia. We genotyped the Leu162Val polymorphism in 1383 patients with type 2
diabetes and 4401 control subjects with normal glucose tolerance (NGT) without showing …