Identification and characterization of acyclovir-resistant clinical HSV-1 isolates from children
Y Wang, Q Wang, Q Zhu, R Zhou, J Liu, T Peng - Journal of clinical virology, 2011 - Elsevier
BACKGROUND: The occurrence of herpes simplex virus (HSV) with acyclovir (ACV)
resistance is a cause for concern due to the frequent use of ACV for treatment, suppressive
therapy, and prophylaxis of HSV infection. Although HSV infection is prevalent among
children, very little is known about the drug susceptibility of HSV circulating in this patient
population. OBJECTIVE: To determine the status of ACV resistant HSV-1 among children.
STUDY DESIGN: A reporter cell-based HSV infection assay (mVILA) was developed to …
resistance is a cause for concern due to the frequent use of ACV for treatment, suppressive
therapy, and prophylaxis of HSV infection. Although HSV infection is prevalent among
children, very little is known about the drug susceptibility of HSV circulating in this patient
population. OBJECTIVE: To determine the status of ACV resistant HSV-1 among children.
STUDY DESIGN: A reporter cell-based HSV infection assay (mVILA) was developed to …