[HTML][HTML] Activation of HIV-1 expression and replication by cGMP dependent protein kinase type 1-β (PKG1β)
JH Lee, VRK Yedavalli, KT Jeang - Retrovirology, 2007 - Springer
JH Lee, VRK Yedavalli, KT Jeang
Retrovirology, 2007•SpringerThe effect of cGMP (cyclic GMP) dependent protein kinase 1-β (PKG1-β) and cGMP
analogues on transcriptional activity and replication of human immunodeficiency virus type 1
(HIV-1) was investigated. Transfection of PKG1β expression plasmid increased expression
from an HIV-1 LTR-reporter as well as from an infectious HIV-1 molecular clone, pNL4-3.
Treatment of HIV-1 AD8-infected monocyte derived macrophages (MDMs) with cGMP
agonists and cGMP antagonists caused respectively increased and decreased virus …
analogues on transcriptional activity and replication of human immunodeficiency virus type 1
(HIV-1) was investigated. Transfection of PKG1β expression plasmid increased expression
from an HIV-1 LTR-reporter as well as from an infectious HIV-1 molecular clone, pNL4-3.
Treatment of HIV-1 AD8-infected monocyte derived macrophages (MDMs) with cGMP
agonists and cGMP antagonists caused respectively increased and decreased virus …
Abstract
The effect of cGMP (cyclic GMP) dependent protein kinase 1-β (PKG1-β) and cGMP analogues on transcriptional activity and replication of human immunodeficiency virus type 1 (HIV-1) was investigated. Transfection of PKG1β expression plasmid increased expression from an HIV-1 LTR-reporter as well as from an infectious HIV-1 molecular clone, pNL4-3. Treatment of HIV-1 AD8-infected monocyte derived macrophages (MDMs) with cGMP agonists and cGMP antagonists caused respectively increased and decreased virus replication. These findings provide evidence that cGMP and PKG serve to regulate HIV-1 infection in human cells.
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