Association of the IFNL4-ΔG Allele With Impaired Spontaneous Clearance of Hepatitis C Virus

PV Aka, MH Kuniholm, RM Pfeiffer… - The Journal of …, 2014 - academic.oup.com
PV Aka, MH Kuniholm, RM Pfeiffer, AS Wang, W Tang, S Chen, J Astemborski, M Plankey…
The Journal of infectious diseases, 2014academic.oup.com
Interferon lambda 4 protein can be generated in IFNL4-ΔG carriers but not IFNL4-TT
homozygotes. We studied 890 anti–hepatitis C virus (HCV)–positive participants in the
Women's Interagency HIV Study. Among blacks (n= 555), HCV was more often cleared for
those with genotype IFNL4-TT/TT (32.6%; odds ratio [OR], 3.59; P= 3.3ื 10− 5) than IFNL4-
TT/ΔG (11.3%; OR, 0.95; P=. 86) or IFNL4-ΔG/ΔG (11.9%; referent). Pooling these data with
published results in blacks (n= 1678), ORs were 3.84 (P= 8.6ื 10− 14) for IFNL4-TT/TT and …
Abstract
Interferon lambda 4 protein can be generated in IFNL4-ΔG carriers but not IFNL4-TT homozygotes. We studied 890 anti–hepatitis C virus (HCV)–positive participants in the Women's Interagency HIV Study. Among blacks (n = 555), HCV was more often cleared for those with genotype IFNL4-TT/TT (32.6%; odds ratio [OR], 3.59; P = 3.3 ื 10−5) than IFNL4-TT/ΔG (11.3%; OR, 0.95; P = .86) or IFNL4-ΔG/ΔG (11.9%; referent). Pooling these data with published results in blacks (n = 1678), ORs were 3.84 (P = 8.6 ื 10−14) for IFNL4-TT/TT and 1.44 (P = .03) IFNL4-TT/ΔG, and the area under the curve was 0.64 for IFNL4-ΔG genotype and 0.61 for rs12979860 (IL28B). IFNL4-ΔG is strongly associated with impaired spontaneous HCV clearance.
Oxford University Press