[HTML][HTML] TH1 immune responses to fully MHC mismatched allografts are diminished in the absence of MyD88, a toll-like receptor signal adaptor protein

BM Tesar, J Zhang, Q Li, DR Goldstein - American Journal of …, 2004 - Elsevier
Toll-like receptors (TLRs) are innate immune receptors that are critical for recognizing
conserved microbial motifs by inducing TH1 immunity. The majority of TLRs utilize the
adaptor protein MyD88 for signal transduction, although other adaptors have been recently
described. As the role of innate immunity in transplantation is unclear, we examined the
importance of the MyD88 pathway in acute rejection of fully MHC-mismatched murine
allografts and specifically investigated whether MyD88 signaling is important for DC …