[HTML][HTML] Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques

NR Klatt, LA Canary, X Sun, CL Vinton… - The Journal of …, 2013 - Am Soc Clin Investig
NR Klatt, LA Canary, X Sun, CL Vinton, NT Funderburg, DR Morcock, M Quiñones
The Journal of clinical investigation, 2013Am Soc Clin Investig
HIV infection results in gastrointestinal (GI) tract damage, microbial translocation, and
immune activation, which are not completely ameliorated with suppression of viremia by
antiretroviral (ARV) therapy. Furthermore, increased morbidity and mortality of ARV-treated
HIV-infected individuals is associated with these dysfunctions. Thus, to enhance GI tract
physiology, we treated SIV-infected pigtail macaques with ARVs, probiotics, and prebiotics
or with ARVs alone. This synbiotic treatment resulted in increased frequency and …
HIV infection results in gastrointestinal (GI) tract damage, microbial translocation, and immune activation, which are not completely ameliorated with suppression of viremia by antiretroviral (ARV) therapy. Furthermore, increased morbidity and mortality of ARV-treated HIV-infected individuals is associated with these dysfunctions. Thus, to enhance GI tract physiology, we treated SIV-infected pigtail macaques with ARVs, probiotics, and prebiotics or with ARVs alone. This synbiotic treatment resulted in increased frequency and functionality of GI tract APCs, enhanced reconstitution and functionality of CD4+ T cells, and reduced fibrosis of lymphoid follicles in the colon. Thus, ARV synbiotic supplementation in HIV-infected individuals may improve GI tract immunity and thereby mitigate inflammatory sequelae, ultimately improving prognosis.
The Journal of Clinical Investigation