Effect of CpG ODN on monocytic myeloid derived suppressor cells
H Shirota, DM Klinman - Oncoimmunology, 2012 - Taylor & Francis
H Shirota, DM Klinman
Oncoimmunology, 2012•Taylor & FrancisCpG oligonucleotides stimulate via TLR9 and enhance anti-tumor immunity, an effect
attributed to the activation of NK and CD8+ T cells. Our recent work demonstrates that CpG
ODN also induce monocytic myeloid-derived suppressor cells to mature into M1
macrophages, further aiding tumor elimination. This provides insight into the mechanism
through which CpG promote tumor regression.
attributed to the activation of NK and CD8+ T cells. Our recent work demonstrates that CpG
ODN also induce monocytic myeloid-derived suppressor cells to mature into M1
macrophages, further aiding tumor elimination. This provides insight into the mechanism
through which CpG promote tumor regression.
CpG oligonucleotides stimulate via TLR9 and enhance anti-tumor immunity, an effect attributed to the activation of NK and CD8+ T cells. Our recent work demonstrates that CpG ODN also induce monocytic myeloid-derived suppressor cells to mature into M1 macrophages, further aiding tumor elimination. This provides insight into the mechanism through which CpG promote tumor regression.
Taylor & Francis Online