[PDF][PDF] Expression of epidermal growth factor receptor and survival in upper aerodigestive tract cancer.

O Dassonville, JL Formento, M Francoual… - Journal of Clinical …, 1993 - Citeseer
O Dassonville, JL Formento, M Francoual, A Ramaioli, J Santini, M Schneider, F Demard…
Journal of Clinical Oncology, 1993Citeseer
Purpose: To determine the expression of epidermal growth factor receptor (EGFR) in head
and neck squamous cell carcinoma and to evaluate its prognostic value. Materials and
Methods: EGFR was determined in tu-mor biopsies obtained from 109 consecutive patients
with head and neck cancer (100 men, nine women). Control biopsies were obtained from 94
patients in a symetric nontumoral area of the same anatomic site. EGFR was measured by a
binding assay using human recombinant iodine 125-EGF. Results: The presence of …
Purpose: To determine the expression of epidermal growth factor receptor (EGFR) in head and neck squamous cell carcinoma and to evaluate its prognostic value.
Materials and Methods: EGFR was determined in tu-mor biopsies obtained from 109 consecutive patients with head and neck cancer (100 men, nine women). Control biopsies were obtained from 94 patients in a symetric nontumoral area of the same anatomic site. EGFR was measured by a binding assay using human recombinant iodine 125-EGF.
Results: The presence of detectable EGFR levels was found in all explored tumors with highly marked differences between patients (median, 71 fminal/mg protein; range, 2 to 2,302). In 93 of 94 cases, EGFR levels were higher in tumor samples as compared with healthy control zones. There was no significant difference in EGFR expression according to the various anatomic sites explored or tumoral differentiation status. There was a
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