[HTML][HTML] Conditional disruption of Pkd1 in osteoblasts results in osteopenia due to direct impairment of bone formation
Z Xiao, S Zhang, L Cao, N Qiu, V David… - Journal of biological …, 2010 - ASBMB
PKD1 (polycystin-1), the disease-causing gene for ADPKD, is widely expressed in various
cell types, including osteoblasts, where its function is unknown. Although global inactivation
of Pkd1 in mice results in abnormal skeletal development, the presence of polycystic kidneys
and perinatal lethality confound ascertaining the direct osteoblastic functions of PKD1 in
adult bone. To determine the role of PKD1 in osteoblasts, we conditionally inactivated Pkd1
in postnatal mature osteoblasts by crossing Oc (osteocalcin)-Cre mice with floxed Pkd1 …
cell types, including osteoblasts, where its function is unknown. Although global inactivation
of Pkd1 in mice results in abnormal skeletal development, the presence of polycystic kidneys
and perinatal lethality confound ascertaining the direct osteoblastic functions of PKD1 in
adult bone. To determine the role of PKD1 in osteoblasts, we conditionally inactivated Pkd1
in postnatal mature osteoblasts by crossing Oc (osteocalcin)-Cre mice with floxed Pkd1 …