Regulation of Bone Mass in Mice by the Lipoxygenase Gene Alox15
RF Klein, J Allard, Z Avnur, T Nikolcheva, D Rotstein… - Science, 2004 - science.org
RF Klein, J Allard, Z Avnur, T Nikolcheva, D Rotstein, AS Carlos, M Shea, RV Waters…
Science, 2004•science.orgThe development of osteoporosis involves the interaction of multiple environmental and
genetic factors. Through combined genetic and genomic approaches, we identified the
lipoxygenase gene Alox15 as a negative regulator of peak bone mineral density in mice.
Crossbreeding experiments with Alox15 knockout mice confirmed that 12/15-lipoxygenase
plays a role in skeletal development. Pharmacologic inhibitors of this enzyme improved
bone density and strength in two rodent models of osteoporosis. These results suggest that …
genetic factors. Through combined genetic and genomic approaches, we identified the
lipoxygenase gene Alox15 as a negative regulator of peak bone mineral density in mice.
Crossbreeding experiments with Alox15 knockout mice confirmed that 12/15-lipoxygenase
plays a role in skeletal development. Pharmacologic inhibitors of this enzyme improved
bone density and strength in two rodent models of osteoporosis. These results suggest that …
The development of osteoporosis involves the interaction of multiple environmental and genetic factors. Through combined genetic and genomic approaches, we identified the lipoxygenase gene Alox15 as a negative regulator of peak bone mineral density in mice. Crossbreeding experiments with Alox15 knockout mice confirmed that 12/15-lipoxygenase plays a role in skeletal development. Pharmacologic inhibitors of this enzyme improved bone density and strength in two rodent models of osteoporosis. These results suggest that drugs targeting the 12/15-lipoxygenase pathway merit investigation as a therapy for osteoporosis.
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