Increased susceptibility to Salmonella infection in signal regulatory protein α-deficient mice

LX Li, SM Atif, SE Schmiel, SJ Lee… - The Journal of …, 2012 - journals.aai.org
LX Li, SM Atif, SE Schmiel, SJ Lee, SJ McSorley
The Journal of Immunology, 2012journals.aai.org
Recent studies have shed light on the connection between elevated erythropoetin
production/spleen erythropoiesis and increased susceptibility to Salmonella infection. In this
article, we provide another mouse model, the SIRPα-deficient (Sirpα−/−) mouse, that
manifests increased erythropoiesis as well as heightened susceptibility to Salmonella
infection. Sirpα−/− mice succumbed to systemic infection with attenuated Salmonella,
possessing significantly higher bacterial loads in both the spleen and the liver. Moreover …
Abstract
Recent studies have shed light on the connection between elevated erythropoetin production/spleen erythropoiesis and increased susceptibility to Salmonella infection. In this article, we provide another mouse model, the SIRPα-deficient (Sirpα−/−) mouse, that manifests increased erythropoiesis as well as heightened susceptibility to Salmonella infection. Sirpα−/− mice succumbed to systemic infection with attenuated Salmonella, possessing significantly higher bacterial loads in both the spleen and the liver. Moreover, Salmonella-specific Ab production and Ag-specific CD4 T cells were reduced in Sirpα−/− mice compared with wild-type controls. To further characterize the potential mechanism underlying SIRPα-dependent Ag-specific CD4 T cell priming, we demonstrate that lack of SIRPα expression on dendritic cells results in less efficient Ag processing and presentation in vitro. Collectively, these findings demonstrate an indispensable role of SIRPα for protective immunity to Salmonella infection.
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