[HTML][HTML] Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection

NJ Tubo, AJ Pagán, JJ Taylor, RW Nelson, JL Linehan… - Cell, 2013 - cell.com
NJ Tubo, AJ Pagán, JJ Taylor, RW Nelson, JL Linehan, JM Ertelt, ES Huseby, SS Way
Cell, 2013cell.com
Summary A naive CD4+ T cell population specific for a microbial peptide: major
histocompatibility complex II ligand (p: MHCII) typically consists of about 100 cells, each with
a different T cell receptor (TCR). Following infection, this population produces a consistent
ratio of effector cells that activate microbicidal functions of macrophages or help B cells
make antibodies. We studied the mechanism that underlies this division of labor by tracking
the progeny of single naive T cells. Different naive cells produced distinct ratios of …
Summary
A naive CD4+ T cell population specific for a microbial peptide:major histocompatibility complex II ligand (p:MHCII) typically consists of about 100 cells, each with a different T cell receptor (TCR). Following infection, this population produces a consistent ratio of effector cells that activate microbicidal functions of macrophages or help B cells make antibodies. We studied the mechanism that underlies this division of labor by tracking the progeny of single naive T cells. Different naive cells produced distinct ratios of macrophage and B cell helpers but yielded the characteristic ratio when averaged together. The effector cell pattern produced by a given naive cell correlated with the TCR-p:MHCII dwell time or the amount of p:MHCII. Thus, the consistent production of effector cell subsets by a polyclonal population of naive cells results from averaging the diverse behaviors of individual clones, which are instructed in part by the strength of TCR signaling.
cell.com