[HTML][HTML] Cholesterol 25-hydroxylation activity of CYP3A
A Honda, T Miyazaki, T Ikegami, J Iwamoto… - Journal of lipid …, 2011 - ASBMB
To date, many studies have been conducted using 25-hydroxycholesterol, which is a potent
regulator of lipid metabolism. However, the origins of this oxysterol have not been entirely
elucidated. Cholesterol 25-hydroxylase is one of the enzymes responsible for the
metabolism of 25-hydroxycholesterol, but the expression of this enzyme is very low in
humans. This oxysterol is also synthesized by sterol 27-hydroxylase (CYP27A1) and
cholesterol 24-hydroxylase (CYP46A1), but it is only a minor product of these enzymes. We …
regulator of lipid metabolism. However, the origins of this oxysterol have not been entirely
elucidated. Cholesterol 25-hydroxylase is one of the enzymes responsible for the
metabolism of 25-hydroxycholesterol, but the expression of this enzyme is very low in
humans. This oxysterol is also synthesized by sterol 27-hydroxylase (CYP27A1) and
cholesterol 24-hydroxylase (CYP46A1), but it is only a minor product of these enzymes. We …