A mutated CCR5 gene may have favorable prognostic implications in MS

R Kantor, M Bakhanashvili, A Achiron - Neurology, 2003 - AAN Enterprises
R Kantor, M Bakhanashvili, A Achiron
Neurology, 2003AAN Enterprises
The authors investigated the association between Δ32CCR5, a mutated allele of the
chemokine receptor CCR5, and disease progression in 256 patients with multiple sclerosis
(MS). The mutated allele frequency in the study cohort was 7.4%, similar to that reported in
the general Israeli population. Progression to disability was prolonged in Δ32CCR5
homozygotes and heterozygotes compared with MS patients with the CCR5 wild-type
genotype (p< 0.005). Mutated CCR5 allele may be considered a favorable prognostic factor …
The authors investigated the association between Δ32CCR5, a mutated allele of the chemokine receptor CCR5, and disease progression in 256 patients with multiple sclerosis (MS). The mutated allele frequency in the study cohort was 7.4%, similar to that reported in the general Israeli population. Progression to disability was prolonged in Δ32CCR5 homozygotes and heterozygotes compared with MS patients with the CCR5 wild-type genotype (p < 0.005). Mutated CCR5 allele may be considered a favorable prognostic factor in MS.
American Academy of Neurology