[HTML][HTML] Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver

M Bektas, ML Allende, BG Lee, WP Chen… - Journal of Biological …, 2010 - ASBMB
The cleavage of sphingoid base phosphates by sphingosine-1-phosphate (S1P) lyase to
produce phosphoethanolamine and a fatty aldehyde is the final degradative step in the
sphingolipid metabolic pathway. We have studied mice with an inactive S1P lyase gene and
have found that, in addition to the expected increase of sphingoid base phosphates, other
sphingolipids (including sphingosine, ceramide, and sphingomyelin) were substantially
elevated in the serum and/or liver of these mice. This latter increase is consistent with a …