[HTML][HTML] Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration
ML Allende, JL Dreier, S Mandala, RL Proia - Journal of Biological …, 2004 - ASBMB
S1P 1 is a widely distributed G protein-coupled receptor whose ligand, sphingosine 1-
phosphate, is present in high concentrations in the blood. The sphingosine 1-phosphate
receptor-signaling pathway is believed to have potent effects on cell trafficking in the
immune system. To determine the precise role of the S1P 1 receptor on T-cells, we
established a T-cell-specific S1P 1 knock-out mouse. The mutant mice showed a block in the
egress of mature T-cells into the periphery. The expression of the S1P 1 receptor was up …
phosphate, is present in high concentrations in the blood. The sphingosine 1-phosphate
receptor-signaling pathway is believed to have potent effects on cell trafficking in the
immune system. To determine the precise role of the S1P 1 receptor on T-cells, we
established a T-cell-specific S1P 1 knock-out mouse. The mutant mice showed a block in the
egress of mature T-cells into the periphery. The expression of the S1P 1 receptor was up …