[HTML][HTML] Phosphorylation and free pool of β-catenin are regulated by tyrosine kinases and tyrosine phosphatases during epithelial cell migration
T Müller, A Choidas, E Reichmann… - Journal of Biological …, 1999 - ASBMB
Cell migration requires precise control, which is altered or lost when tumor cells become
invasive and metastatic. Although the integrity of cell-cell contacts, such as adherens
junctions, is essential for the maintenance of functional epithelia, they need to be rapidly
disassembled during migration. The transmembrane cell adhesion protein E-cadherin and
the cytoplasmic catenins are molecular elements of these structures. Here we demonstrate
that epithelial cell migration is accompanied by tyrosine phosphorylation of β-catenin and an …
invasive and metastatic. Although the integrity of cell-cell contacts, such as adherens
junctions, is essential for the maintenance of functional epithelia, they need to be rapidly
disassembled during migration. The transmembrane cell adhesion protein E-cadherin and
the cytoplasmic catenins are molecular elements of these structures. Here we demonstrate
that epithelial cell migration is accompanied by tyrosine phosphorylation of β-catenin and an …