[HTML][HTML] Endogenous expansion of regulatory T cells leads to long-term islet graft survival in diabetic NOD mice
Donor pancreatic lymph node cells (PLNC) protect islet transplants in Non-obese diabetic
(NOD) mice. We hypothesized that induced FoxP3+ regulatory T cells (Tregs) were required
for long-term islet engraftment. NOD or NOD. NON mice were treated with ALS
(antilymphocyte serum) and transplanted with NOR islets+/–PLNC (5× 10 7). In vivo
proliferation and expansion of FoxP3+ Tregs was monitored in spleen and PLN from ALS-
and ALS/PLNC-treated recipient mice. Anti-CD25 depletion was used to determine the …
(NOD) mice. We hypothesized that induced FoxP3+ regulatory T cells (Tregs) were required
for long-term islet engraftment. NOD or NOD. NON mice were treated with ALS
(antilymphocyte serum) and transplanted with NOR islets+/–PLNC (5× 10 7). In vivo
proliferation and expansion of FoxP3+ Tregs was monitored in spleen and PLN from ALS-
and ALS/PLNC-treated recipient mice. Anti-CD25 depletion was used to determine the …