[HTML][HTML] Correction of defective host response to Mycobacterium bovis BCG infection in TNF-deficient mice by bone marrow transplantation
M Jacobs, MW Marino, N Brown, B Abel… - Laboratory …, 2000 - Elsevier
Tumour necrosis factor-α (TNF) plays a central role in the recruitment and activation of
mononuclear cells in mycobacterial infection. In the absence of type 1 TNF receptor,
Mycobacterium bovis Bacillus Calmette–Guérin (BCG) infection of mice is not contained,
leading to fatal disease. Because type 1 TNF receptor binds both TNF and lymphotoxin-α,
we used TNF-deficient mice to determine the specific role of TNF in the host resistance to
BCG infection. The bacterial burden of the lungs of TNF-deficient mice was substantially …
mononuclear cells in mycobacterial infection. In the absence of type 1 TNF receptor,
Mycobacterium bovis Bacillus Calmette–Guérin (BCG) infection of mice is not contained,
leading to fatal disease. Because type 1 TNF receptor binds both TNF and lymphotoxin-α,
we used TNF-deficient mice to determine the specific role of TNF in the host resistance to
BCG infection. The bacterial burden of the lungs of TNF-deficient mice was substantially …