Efficacy of membrane TNF mediated host resistance is dependent on mycobacterial virulence
I Dambuza, N Allie, L Fick, N Johnston, C Fremond… - Tuberculosis, 2008 - Elsevier
TNF is required for protection against virulent and non-virulent mycobacterial infections.
Here we compared the effect of Tm-TNF and sTNF, two different molecular forms of TNF, in
virulent and non-virulent murine challenge models. Using non-virulent Mycobacterium bovis
BCG intranasal infection we established that immunity is durably compromised in Tm-TNF
mice, with augmented bacilli burden, leading to chronic but non-lethal infection. Acute
infection by a virulent Mycobacterium tuberculosis low-dose aerosol challenge was …
Here we compared the effect of Tm-TNF and sTNF, two different molecular forms of TNF, in
virulent and non-virulent murine challenge models. Using non-virulent Mycobacterium bovis
BCG intranasal infection we established that immunity is durably compromised in Tm-TNF
mice, with augmented bacilli burden, leading to chronic but non-lethal infection. Acute
infection by a virulent Mycobacterium tuberculosis low-dose aerosol challenge was …